This web page was produced as an assignment for Gen677 at UW-Madison Spring 2009.
Human Protein Network Homologous Protein Networks
Chicken
Mouse
Rhesus Monkey
The three homologous networks presented, share some common features with human SRD5A2. The chicken is the most basic, but shares half of the interacting genes with that of the human. The CYP protein is an estrogen synthetase, and the UGT is a UDP-gucuronosyltransferase. The mouse is even more complex and adds an extensive network of hydroxysteroid dehydrogenases to its interaction network. Finally, the Rhesus monkey has the most complex, yet most similar interaction network as the human. Unfortunately, these do not seem to give insight in to the condition of balding. Rather the conserved interactions across organisms appear to be very tightly linked in the regulation of hormone levels. Its clear that an abundance of testosterone can lead to androgenic alopecia, but blocking it will cause too many other problems. The only possible solution using these regulatory enzymes would be to find a balance of reduce hormone levels and otherwise normal functioning to see if that has an effect on hair loss.
