This web page was produced as an assignment for Gen677 at UW-Madison Spring 2009.
Home Page
1. Norwood, O'tar T. (1975) Male Pattern Baldness: classification and Incidence. Southern medical journal, 68(11):1359-1365
2. Hoffman, R. (2002). Male Androgenetic Alopecia. Clinical and Experimental dermatology, 27(5): 373-382. doi:10.1046/j.1365-2230.2002.01086.x
3. Stough, D., Stenn, K., Haber, R., Parsley, W.M., Vogel, J.E., Whiting, D.A., & Washenik, K. (2005). Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men. Mayo Clin Proc., 80(10):1316-1322. doi:10.4065/80.10.1316
4. Nyholt, R.D., Gillespie, N.A., Heath, A.C., and Martin, N.G. (2003) Genetic Basis of Male Pattern Baldness. Journal of Investigative Dermatology, 121:1561-1564. doi:doi:10.1111/j.1523-1747.2003.12615.x
5. Kaufman, K.D. (2002) Androgens and Alopecia. Molecular and Clinical Endocrinology, 198(10):89-95. doi:10.1016/S0303-7207(02)00372-6
In the News
Zdeb, Chris. (2009, January 26). For Some, Losing Hair Prematurely is Losing Out. The Edmonton Journal. Retrieved from The Edmonton Journal
Supported by Science
Cash, T.F. British Journal of Dermatology. September, 1999. Volume 141(3):398-405. doi:10.1046/j.1365-2133.1999.03030.x
Genetic Discourses
1. http://www.GeneCards.org
2. http://www.ncbi.nlm.nih.gov/Homologene
3. Occhiato, E.G., Guarna, A., Danza, G., and Serio, M. (2004) Selective non-steroidal inhibitors of 5alpha-reductase type 1. The jouranl of Biochemistry and Molecular Biology. 88:1(1-16), doi10.1016/j.jsbmb.2003.10.004
4. Dereeper A.*, Guignon V.*, Blanc G., Audic S., Buffet S., Chevenet F., Dufayard J.F., Guindon S., Lefort V., Lescot M., Claverie J.M., Gascuel O. Phylogeny.fr: robust phylogenetic analysis for the non-specialist. Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W465-9. Epub 2008 Apr 19. (PubMed) *: joint first authors
5. Russell, D. W., and Wilson, J.D. 1994. Steroid 5alpha-Reductase:Two genes/Two Enzymes. Annu. Rev. Biochem. 63:25-61, doi:10.1146/annurev.bi.63.070194.000325
6. Dereeper A.*, Guignon V.*, Blanc G., Audic S., Buffet S., Chevenet F., Dufayard J.F., Guindon S., Lefort V., Lescot M., Claverie J.M., Gascuel O. Phylogeny.fr: robust phylogenetic analysis for the non-specialist. Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W465-9. Epub 2008 Apr 19. (PubMed) *: joint first authors
7. Edgar RC. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 2004, Mar 19;32(5):1792-7. (PubMed)
8. Castresana J. Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. Mol Biol Evol. 2000, Apr;17(4):540-52. (PubMed)
9. Guindon S., Gascuel O. A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol. 2003, Oct;52(5):696-704. (PubMed)
10. Anisimova M., Gascuel O. Approximate likelihood ratio test for branchs: A fast, accurate and powerful alternative. Syst Biol. 2006, Aug;55(4):539-52. (PubMed)
11. Li, et al. 2006. TreeFam: a curated database of phylogenetic trees of animal gene families. Nucleic Acids Res. Jan 1; 34(database issue):D572-80.
12. Markridakis, N.M., Caldas Ferraz, L.F., and Reichardt, J.K. 2009. Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif. Hum Mutat. 30(1):39-48
13. http://motif.genome.jp
14. http://meme.sdsc.edu/meme4/intro.html
Phenoype/Ontology
1. Yi, W., Ross, J.M., Zarkower, D. 2000. Mab-3 is a direct tra-1 target gene regulating diverse aspects of C. elegans male sexual development and behavior. Devlopment. 127:20(4469-4480)
2. Andersson S, Berman DM, Jenkins EP, Russell DW (1991). "Deletion of steroid 5 alpha-reductase 2 gene in male pseudohermaphroditism.". Nature 354 (6349): 159–61. doi:10.1038/354159a0
3. Gene Expression Omnibus (GEO)
4. Wormbase
5. The Gene Ontology:AmiGO
Protein Data
1. Expasy
2. Uniprot
3. Chang, A. et al. BRENDA, AMENDA, and FRENDA the enzyme information system: new content and tools in 2009. 2009. Nucleic Acids Res. 37:D588-D592. BRENDA
4. GenomeNet
5. The Pfam protein families database: R.D. Finn, J. Tate, J. Mistry, P.C. Coggill, J.S. Sammut, H.R. Hotz, G. Ceric, K. Forslund, S.R. Eddy, E.L. Sonnhammer and A. Bateman Nucleic Acids Research (2008) Database Issue 36:D281-D288
6. PROSITE
7. Russell, D. W., and Wilson, J.D. 1994. Steroid 5alpha-Reductase:Two genes/Two Enzymes. Annu. Rev. Biochem. 63:25-61, doi:10.1146/annurev.bi.63.070194.000325
8. Keil, B. Specificity of Proteolysis. Springer-Verlag Berlin-Heidelberg-NewYork, pp.335. (1992)
9. Transmembrane helice prediction:TMHMM
Protein Network
1. Park, J. et al. Deletion Polymorphism of UDP-Glucuronosyltransferase 2B17 and Risk of Prostate Cancer in African American and Caucasian Men. 2006. Cancer Epidemiol Biomarkers Prev. 15(8):1473-8
2. Jensen et al. STRING 8--a global view on proteins and their functional interactions in 630 organisms. 2009. Nucleic Acids Res. 37:D412-6. http://string.embl.de
Knowing and Treating
1. www.minoxidil.com
2. www.showcatsonline.com/x/minoxidil.shtml
3. Merck & Co.: Propecia
4. GlaxoSmithKline: Dutasteride
5. HairDX
Plant Page
1. Li, J., Biswas, M.G., Chao, A., Russell, D.W., and Chory, J. (1997) Conservation of function between mammalian and plant steroid 5 alpha reductases. Proc. Natl. Acad. Sci. 94:3554-3559
2. Chory, J., Nagpal, P., and Peto, C.A. 1991. Phenotypic and Genetic Analysis of det-2, a new mutation that affects light regulated seedling development in Arabidopsis. The Plant Cell. 3(5):445
